Researchers
Carmella Evans-Molina, MD, PhD Assistant Professor of Medicine, Department of Medicine
Assistant Professor of Medicine: Department of Medicine Division of Endocrinology and Metabolism
Undergraduate: BS, Pharmacy, West Virginia University: Morgantown, WV (1996)
Medical School: MD, Marshall University School of Medicine: Huntington, WV (2001)
Residency: Internal Medicine, Massachusetts General Hospital: Boston, MA (2001-2004)
Fellowship and Postdoctoral Training: Endocrinology, Diabetes, and Metabolism, University of Virginia: Charlottesville, VA (2004-2007). Mentor: Raghu Mirmira, MD, PhD
Graduate: MS Biological Sciences, The University of Virginia (2008); PhD Pharmacology, The University of Virginia: Charlottesville, VA (2009).
Graduate Advisor: Raghu Mirmira, MD, PhD Thesis Title: Transcriptional Regulation of the Beta Cell in Health and Disease.
E-mail: cevansmo@iupui.edu
Research Interests:
The incidence of diabetes mellitus in our country is increasing in epidemic proportions. The efforts in our lab are focused on three key aspects of research related to diabetes: 1. Transcriptional regulation of beta cell function: Our work in this area focuses on the regulation of genes involved in beta cell function and the interplay between chromatin modulation and gene expression. 2. Novel stem-cell based therapies for Type 1 diabetes: Through collaborative efforts with researchers at the Indiana Center for Vascular Biology and Medicine, projects are underway to investigate the paracrine effects of tissue specific stem cells in preserving beta cell mass and function following islet transplantation. 3. Epigenetic mechanisms of diabetic macrovascular complications: We are beginning projects to examine the role of Set7/9, a histone methyltransferase, in the sustained activation of NF-kB dependent inflammatory pathways in response to hyperglycemia in macrophages and endothelial cells.
