Grzegorz Nalepa, MD, PhD

Phone: 317-278-9290
Office: R4 421

Grzegorz Nalepa, MD, PhD

Assistant Professor of Pediatrics

Division of Pediatric Hematology-Oncology

Assistant Professor of Medical and Molecular Genetics

Assistant Professor of Biochemistry



  • MD: Silesian School of Medicine
  • PhD: Baylor College of Medicine, Houston, TX
  • Postdoctorate: Harvard Medical School, Boston, MA

Selected Awards

2012 David G. Nathan Award in Basic Research
2012 CTSI Young Investigator Award
2011 Red Shoes Award, Riley Hospital for Children
2006-2012 Morris Green Academic Scholarship Award

Research Interest:

Our research is focused on the identification of signaling pathways responsible for the evolution of genomic instability leading to cancer and bone marrow failure in patients with Fanconi anemia (FA) and other inherited bone marrow failure syndromes. We were the first to show that FA signaling is essential for error-free function of the spindle assembly checkpoint (SAC), which – together with the work of others – indicates that the FA network functions as the anti-cancer guardian of genome stability throughout the cell cycle. We are dissecting the mechanistic and translational impact of this finding via a multidisciplinary approach that includes functional genomics, generation of new animal models of FA and superresolution microscopy imaging. We hope our research will lead to better understanding of the complex FA signaling network and to development of targeted therapies for FA and spontaneous cancers resulting from somatic loss of FA signaling.

Nalepa Lab