Jianjian Shi, MD
Senior Research Professor
Primary Appointment: Department of Pediatrics
- M.D.: Xiangya School of Medicine, Central South University, China. Certified (2001) by ECFMG (United States Educational Commission for Foreign Medical Graduates)
- Medical Research Fellowship of the Ministry of Health:Medical Research Program in Biochemistry, Ministry of Health, People's Republic of China
- M.Sc. Biochemistry/Hematology, Xiangya School of Medicine, Central South University, China
- Postdoctoral Fellowship:Institute of Biosciences and Technology, Texas A&M University, Houston, USA
- Research Fellow III:University of Texas Medical School, Houston, TX, USA.
Current Research Interests:
ROCK family has recently emerged as a potential therapeutic targets for metabolic disorders, cardiovascular disease, cancers, glaucoma, et al.. My current research focus is to understand the molecular basis of metabolic disorders with the aims to develop a novel therapy for insulin resistance, diabetes and obesity. Obesity is a major global health challenge, and contributes to the rising prevalence of type 2 diabetes, hypertension, cardiovascular disease, and certain cancers. We are concentrating on ROCK isoform functions in the disease pathogenesis which is critical for design a novel therapeutic stratagem. Projects comprise the investigation of the roles of ROCK isoforms in glucose and lipid metabolism, insulin resistance, and in obesity prevention/treatment; the systemic ROCK isoform knockout and kinase-dead knockin mouse models, as well as tissue-specific ROCK isoform knockout mouse models are essential and available in our laboratory; the funding from the CTSI for our research using the CTSI Core facilities is very helpful for us to successfully move forward for higher levels. We expect to provide novel insight into raising translational potential of ROCK isoform-selective inhibitors for precise disease prevention and treatment.
My long term research effort on ROCK signaling pathway and metabolic disease has been strongly connected with developing treatment and prevention of human diseases through research collaborating with numerous researchers in Wells Center for Pediatric Research, IUSM or other institutions, which comprises a broad spectrum of disciplines, including heart failure, hematologic disease, immunologic disease, endocrine disease, and stem cell biology.