Chandy C. John, MD, MS

Professor of Pediatrics

Professor of Microbiology and Immunology

Clinical Section: Ryan White Center for Pediatric Infectious Disease and Global Health


  • MS: Epidemiology, School of Graduate Studies, Case Western Reserve University
  • Fellowship:Pediatric Infectious Diseases, Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH
  • Residency: Internal Medicine and Pediatrics, University of Michigan, Ann Arbor, MI
  • MD: University of Michigan Medical School, Ann Arbor, MI

Research Interest:

The John Lab is a collaborative research group that does research studies in Uganda with Makerere University and Global Health Uganda and in Kenya with the Kenya Medical Research Institute and Maseno University. The John Lab focuses on the following major questions related to malaria:

  • Which host and pathogen factors contribute to development of severe malaria?
  • How does the immune response to malaria contribute to long-term neurodevelopmental impairment in children with severe malaria?
  • How can iron deficiency be safely treated in malaria endemic areas?
  • What contributes to the increased risk of death from malaria in children with sickle cell disease?
  • How do changing transmission conditions affect development of immunity in malaria?

Dr. John’s lab investigates how malaria immunity develops, why severe malaria occurs, which factors lead to impaired neurodevelopment in children with malaria, and how malaria interacts with other disease states like iron deficiency and sickle cell disease.

Ongoing Projects:
  1. Neurodevelopmental outcomes in severe malaria, NIH R01 NS055349

    Principal Investigator (PI): Chandy John, Co-investigators (Co-I): Robert Opoka, Richard Idro This study seeks to identify the immunologic and genetic factors associated with cognitive and neurologic deficits in children with severe malaria.

  2. Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM), Doris Duke Foundation ICRA 2013139

    PI: Chandy C. John; Co-I: Christopher Ndugwa, Russell Ware, Robert Opoka, Heather Hume, Phillip Kasirye. This randomized, placebo-controlled, double-blinded clinical trial assesses the safety and efficacy of hydroxyurea treatment for Ugandan children with sickle cell disease. The safety focus of the trial is on the risk of malaria in children receiving hydroxyurea.

  3. Malaria Chemoprevention for the post-discharge management of severe anaemia in children in Malawi, Uganda and Kenya: Moving towards policy

    PI: Phiri, Kamija. Co-I: Chandy C. John, Feiko ter Kuile, Bjarne Robbestad, Meghna Desai, Simon Kariuki, Richard Idro, Robert Opoka This placebo controlled, randomized clinical trials aims to determine whether post-discharge malaria chemoprevention for children with severe anemia can reduce the risk of readmission in these children.

  4. Acute vs. delayed iron therapy: effect on iron status, anemia and cognition, NIH U01 HD064698

    PI: Chandy John, Co-I: Robert Opoka, Sarah Cusick This study aims to determine the effects of acute vs. 1-month delayed iron therapy in children with iron deficiency and severe malaria on iron status, anemia and long-term cognition.

  5. Malaria transmission and immunity to P. falciparum and prevalence of anemia

    PI: Chandy John, Co-I: John Vulule, George Ayodo This study assesses how malaria transmission affects immune response and hemoglobin level. Training Grants

  6. Research Training in Infection and Neurodevelopment, NIH D43 NS078280

    PI: Chandy C. John, Co-I: Richard Idro, Sarah Kiguli This grant provides doctoral level training for students in neuropsychology, immunology, biostatistics, and epidemiology, as well as provide training in mentorship for faculty members at Makerere University.

  7. Northern and Pacific Universities Global Health Research Training consortium, NIH R25TW009345

    PIs: Joseph Zunt, Chandy C. John, Joseph Kolars, Vivek Nerurkar This grant supports training of post-doctoral fellows and doctoral students in global health research. The training consortium includes the Universities of Washington, Minnesota, Michigan and Hawaii. Uganda and Kenya are partner countries.