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Loren J. Field, PhD

Email: ljfield@iu.edu
Phone: 317-274-5085
Office: R4-376

Loren J. Field, PhD

Professor of Medicine and Pediatrics

Indiana University School of Medicine

 

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 Education

  • B.A.: State University of New York at Oswego
  • M.S.: Cell & Molecular Biology (1980), State University of New York at Buffalo
  • Ph.D.:Cell & Molecular Biology (1982), State University of New York at Buffalo
  • Postdoctoral Fellowship:Biology, Roswell Park Memorial Institute, Buffalo, New York
  • Staff and Senior Staff Investigator:Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

Research Interest:

Although the adult mammalian heart retains some capacity for cardiomyocyte renewal (resulting predominately from cardiomyocyte), the magnitude of this regenerative process is insufficient to effect repair of substantively damaged hearts. My lab has a long standing interest in developing strategies to induce regenerative growth, and developing strategies to promote cardioprotection. We have focused on two approaches to promote regenerative growth. The first entails inducing proliferation in surviving cardiomyocytes following myocardial injury. Towards that end we have identified a number of gene products which, when expressed in cardiomyocytes, induce proliferation. The second approach to promote regenerative growth focuses on the transplantation of donor cells into injured hearts. Towards that end we have shown that fetal cardiomyocytes or cardiomyogenic stem cells can functionally integrate when injected into normal or damaged myocardium. We have also invested considerable effort in developing strategies to promote cardioprotection, particularly in response to cardiotoxic drugs (as exemplified by anthracyclines) .

 

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