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Mohammad Reza Saadatzadeh, PhD

Assistant Research Professor of Pediatrics

Technical Coordinator of the Brain Tumor Working Group, Indiana University

Primary Appointment: Department of Pediatrics

Joint Appointment: Department of Pediatrics & Neurosurgery

Education

  • Post-doctoral Research: Indiana University School of Medicine, Indianapolis, IN
  • PhD:Microbiology/ Immunology, Leeds University, Leeds, United Kingdom
  • MSc:Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
  • BSc:Clinical Laboratory Sciences (Medical Technology), Isfahan University of Medical Sciences, Isfahan, Iran

Current Research Interests:

My research interests focus on novel combination treatments that build upon the standard-of-care for pediatric and adult GBM. We are utilizing genomically-characterized 3D GBM neurospheres grown under hypoxia to study response and underlying mechanisms of response to novel multi-targeted therapies. The neurospheres contain rare stem-like tumor cells that are particularly resistant to current therapies. We have identified new therapies that target the DNA Damage Response and have the potential to halt the growth of GBM cells. We are conducting both in vitro mechanistic studies and in vivo orthotopic humanized models to test and refine new therapies for eradicating GBM. I serve as the Technical Coordinator for the Brain Tumor Working Group to build and to bridge the gap between the clinic and the research bench. In this capacity I work with Drs. Pollok (Pediatrics) and Cohen-Gadol (Neurosurgery) to develop innovative approaches to studying therapy-resistant glioblastoma. In conjunction with the IUSCC tissue bank, I am responsible for developing and characterizing new primary patient cell lines derived from patient specimens obtained through Dr. Cohen-Gadol and the neurosurgery department.

Mohammad, PhD
E-mail:msaadatz@iu.edu
Office: 317-274-8914
Lab:317-274-8966
Address: 1044 West Walnut Street, R4-W319, Indianapolis, IN 46202