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Patrick T. Fueger PhD

E-mail: pfueger@iu.edu
Phone: 317-274-7862
Office: MS 2049

Patrick T. Fueger, PhD

Assistant Professor of Pediatrics

Assistant Professor:Department of Cellular and Integrative Physiology

Co-Director, Bioengineering Interdisciplinary Training Program for Diabetes Research

Director Molecular Medicine in Action

Member, Herman B. Wells Center for Pediatric Research

Executive Committee Member, Center for Diabetes and Metabolic Diseases

Research Group Website: Diabetes

Education

  • B.S.: University of Wisconsin-Milwaukee
  • M.S.: University of Wisconsin-Milwaukee
  • PhD: Vanderbilt University
  • Postdoctorate: Duke University

Research Interest:

The mission of my laboratory is to identify molecular mechanisms regulating glucose homeostasis during health and disease (e.g., diabetes). To do this, we have research programs aimed at: 1) preventing metabolic dysregulation in insulin responsive tissues such as skeletal muscle and liver, and 2) maintaining and restoring functional beta cell mass. We have a particular interest in endogenous, negative feedback regulators of pathways (i.e. molecular brakes) and are investigating how these proteins modulate cellular survival, repair, regeneration, and function. Currently we have been focusing our efforts on the cell cycle inhibitor p21 and the EGFR inhibitor Mig6 (Mitogen-inducible gene 6, or errfi1). All of our work fits within a framework of using cellular and molecular techniques to explore integrative physiology and metabolism.

We are currently exploring the following topics:

  • Role of Mig6 and p21 in glucolipotoxicity of pancreatic beta cells associated with type 2 diabetes
  • Defining how Mig6 compromises beta cell survival, function, and regeneration in type 1 diabetes
  • Role of Mig6 in hepatic metabolism, survival, and regeneration
  • Identifying novel beta cell growth factors and mediators of cellular survival and repair
  • Establishing the mechanisms for impairments of receptor tyrosine kinase signaling in obesity

Dr. Fueger's Laboratory