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Sarah Tersey, PhD

Associate Research Professor of Pediatrics

Associate Director, Islet and Physiology Core

Primary Appointment: Department of Pediatrics

Education

  • Postdoctoral Fellowship: University of Virginia, Charlottesville, VA
  • Postdoctoral Fellowship: Massachusetts General Hospital; Harvard Medical School, Boston, MA
  • PhD: University of Massachusetts, Amherst

Current Research Interests:

The primary goal of my research focuses on understanding the molecular pathways that play a role in the development of diabetes. Specifically, pathways that include the enzymes 12-lipoxygenase and deoxyhypusine synthase. By using inhibitors against the pathways or creating genetic deletions of either of these genes, I have shown that diabetes can be prevented. A second major focus of my research is the development of biomarkers that will best predict the likelihood of any one individuals risk to develop type 1 diabetes. Within this concept, I demonstrated that the dysfunction of the pancreatic islet precedes the onset of type 1 diabetes. This research has changed the standard dogma of the islet as a silent bystander to the immune system, to the new way to thinking that the islet is a major player in its own demise during the pre-course of type 1 diabetes. We have also utilized this concept and developed a novel biomarker to predict diabetes in both a mouse model of type 1 diabetes and human individuals with new onset type 1 diabetes.

Tersey, PhD
E-mail:stersey@iu.edu
Office: 317-278-8944
Lab:317-278-8940
Address: 635 Barnhill Dr, MS2031, Indianapolis, IN 46202