Stephanie M. Ware, MD PhD, FACMG
Professor of Pediatrics
Professor of Medical and Molecular Genetics
Program Leader for Cardiovascular Genetics Indiana University School of Medicine
Clinical Section http://genetics.medicine.iu.edu
- B.S.: Butler University
- PhD: University of Cincinnati College of Medicine
- MD: University of Cincinnati College of Medicine
- Residency in Pediatrics: Baylor College of Medicine
- Fellowship in Genetics: Baylor College of Medicine
Stephanie M. Ware, MD, PhD is a clinical geneticist who has research programs that focus on the genetic and developmental basis of pediatric heart disease. The two main areas of interest are disorders of cardiac function (cardiomyopathies) and structure (congenital heart disease). The laboratory utilizes animal models to investigate the developmental mechanisms and pathobiology of these disorders. The lab is specifically interested in developmental pathways important for normal left-right patterning and cardiac looping during embryogenesis. Translational research on congenital heart defects aims to investigate and identify novel genes underlying cardiovascular malformations using genome-wide analyses. High priority candidate genes identified by this approach are validated using high throughput screens in Xenopus, with novel candidates being further evaluated in mouse models of disease. Dr. Ware also coordinates the Cytogenomics of Cardiovascular Malformations Consortium, a highly collaborative alliance of outstanding academic pediatric cardiovascular genetic centers that have developed a clinical cytogenetic registry with deep cardiac phenotyping. Research efforts in cardiomyopathy are focused on identifying novel causes of pediatric cardiomyopathy, delineating genetic modifiers utilizing genomic technologies for functional annotation and validation of genetic variants.
As the Program Leader in Cardiovascular Genetics, Dr. Ware coordinates clinical genetic services for patients with cardiomyopathy, genetic syndromic conditions, aortopathy and vascular disorders, and inherited arrhythmias.