Yongzheng He, MD
Research Assistant Professor of Pediatrics
- M.D:Hunan Medical University, China
Current Research Interests:
I am currently a Research Assistant Professor in the laboratory of Dr. David W. Clapp. The Clapp laboratory’s major area of focus is understanding the molecular pathogenesis of neurofibromatosis type 1 (NF1) by utilizing genetically engineered modified mouse models (GEMMs) that fully recapitulates the NF1 disease phenotype by four months of age. In utilizing in vitro techniques I previously learned as an Research Associate Professor in Dr. Feng-Chun Yang’s laboratory, as well as the techniques associated with developing GEMMs in Dr. Clapp’s laboratory, my research is focused on understanding the biochemical tumor suppressor function of the NF2 gene and utilizing genetic and pharmacologic strategies to treat Schwannoma formation in using murine models of NF2. I have extensive experience in immunophenotypic studies using immunofluorescence microscopy, flow cytometry and performing the in vivo animal study, as well as in vitro cell functional and molecular analysis outlined in this proposal. The data generated from these studies will allow me to analysis the role of Yes associated protein (Yap) in Schwannoma microenvironment and investigate the impact of Yap deletion on NF2 disease.
Office: 1044 West Walnut Street, R4-414A, Indianapolis, IN 46202